Involvement of gangliosides in lymphocyte stimulation.

Human tumor gangliosides inhibit murine immune responses in vivo.

Gangliosides which are shed by tumor cells clearly inhibit cellular immune responses in vitro. However, the immunosuppressive activity of these molecules have been more difficult to ascertain in vivo. Here we have adapted a murine model to determine the effects of tumor gangliosides in an in vivo microenvironment, the lymph node draining the site of stimulation by allogeneic cells. In this mode...

Lack of specificity of brain gangliosides in the modulation of lymphocyte activation.

A potential role for glycolipid gangliosides to act as immunomodulating agents has been suggested. Most studies have employed brain gangliosides. We have systematically investigated highly purified murine brain gangliosides for their ability to modulate lymphocyte activation. All sialic acid classes of ganglioside inhibited lipopolysaccharide (LPS)-induced antibody secretion and all polysialate...

Inhibition of mitogen- and antigen-induced lymphocyte activation by human leukemia cell gangliosides.

Human leukemia cell gangliosides were found to inhibit in vitro activation of human lymphocytes by lectins and the soluble antigen Candida albicans at concentrations as low as 2 micrograms/2 X 10(5) lymphocytes/0.2-ml cultures. The inhibition was not due to a reduction in the number of viable cells, but to an inhibition of blast formation. Three gangliosides were purified from the original mixt...

Detection of Autoantibodies against Gangliosides in Guillain-Barré Syndrome

A SURVEY OF CELLULAR IMMUNITY, TOTAL T-LYMPHOCYTE, T-ACTIVE , B-LYMPHOCYTE A ND T-CELL FUNCTION IN RELATION TO PHYTOHEMAGGLUTININ (PHA) IN THALASSEMIC PATIENTS

The aim of this study was to evaluate the immune system and lymphocyte function in 41 Iranian β-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. The patients consisted of 20 splenectomized and 21 non-splenectomized patients. They were treated with Desferal, and had received repeated blood transfusion. Laboratory investigations included measurement of total T lymphocyt...